Heterotrimeric G Proteins: Breaking the rules of engagement, space and time

Autor Midde, Krishna K., Aznar, Nicolas, Kalogriopoulos, Nicholas, Ghosh, Pradipta
Vydáno v Bioessays (2016)

A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin

Autor Aznar, Nicolas, Sun, Nina, Dunkel, Ying, Ear, Jason, Buschman, Matthew D., Ghosh, Pradipta
Vydáno v Mol Biol Cell (2017)

Protein kinase C-theta (PKCθ) phosphorylates and inhibits the guanine exchange factor, GIV/Girdin

Autor López-Sánchez, Inmaculada, Garcia-Marcos, Mikel, Mittal, Yash, Aznar, Nicolas, Farquhar, Marilyn G., Ghosh, Pradipta
Vydáno 2013

Multimodular biosensors reveal a novel platform for activation of G proteins by growth factor receptors

Autor Midde, Krishna K., Aznar, Nicolas, Laederich, Melanie B., Ma, Gary S., Kunkel, Maya T., Newton, Alexandra C., Ghosh, Pradipta
Vydáno v Proc Natl Acad Sci U S A (2015)

Prognostic impact of total and tyrosine phosphorylated GIV/Girdin in breast cancers

Autor Dunkel, Ying, Diao, Kexin, Aznar, Nicolas, Swanson, Lee, Liu, Lawrence, Zhu, Wenhong, Mi, Xiao-yi, Ghosh, Pradipta
Vydáno v FASEB J (2016)

Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma

Autor Dunkel, Ying, Reid, Anna L., Ear, Jason, Aznar, Nicolas, Millward, Michael, Gray, Elin, Pearce, Robert, Ziman, Melanie, Ghosh, Pradipta
Vydáno v Sci Rep (2018)

Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin

Autor Lin, Changsheng, Ear, Jason, Midde, Krishna, Lopez-Sanchez, Inmaculada, Aznar, Nicolas, Garcia-Marcos, Mikel, Kufareva, Irina, Abagyan, Ruben, Ghosh, Pradipta
Vydáno v Mol Biol Cell (2014)

Mitochondrial BMI1 maintains bioenergetic homeostasis in cells

Autor Banerjee Mustafi, Soumyajit, Aznar, Nicolas, Dwivedi, Shailendra Kumar Dhar, Chakraborty, Prabir Kumar, Basak, Rumki, Mukherjee, Priyabrata, Ghosh, Pradipta, Bhattacharya, Resham
Vydáno v FASEB J (2016)

Therapeutic effects of cell-permeant peptides that activate G proteins downstream of growth factors

Autor Ma, Gary S., Aznar, Nicolas, Kalogriopoulos, Nicholas, Midde, Krishna K., Lopez-Sanchez, Inmaculada, Sato, Emi, Dunkel, Ying, Gallo, Richard L., Ghosh, Pradipta
Vydáno v Proc Natl Acad Sci U S A (2015)

Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity

Autor Ma, Gary S., Lopez-Sanchez, Inmaculada, Aznar, Nicolas, Kalogriopoulos, Nicholas, Pedram, Shabnam, Midde, Krishna, Ciaraldi, Theodore P., Henry, Robert R., Ghosh, Pradipta
Vydáno v Mol Biol Cell (2015)

AMP-activated protein kinase fortifies epithelial tight junctions during energetic stress via its effector GIV/Girdin

Autor Aznar, Nicolas, Patel, Arjun, Rohena, Cristina C, Dunkel, Ying, Joosen, Linda P, Taupin, Vanessa, Kufareva, Irina, Farquhar, Marilyn G, Ghosh, Pradipta
Vydáno v eLife (2016)

Convergence of Wnt, growth factor and trimeric G protein signals on Daple

Autor Aznar, Nicolas, Ear, Jason, Dunkel, Ying, Sun, Nina, Satterfield, Kendall, He, Fang, Kalogriopoulos, Nicholas, Lopez-Sanchez, Inmaculada, Ghassemian, Majid, Sahoo, Debashis, Kufareva, Irina, Ghosh, Pradipta
Vydáno v Sci Signal (2018)

Pemetrexed Hinders Translation Inhibition upon Low Glucose in Non-Small Cell Lung Cancer Cells

Autor Piecyk, Marie, Triki, Mouna, Laval, Pierre-Alexandre, Dragic, Helena, Cussonneau, Laura, Fauvre, Joelle, Duret, Cédric, Aznar, Nicolas, Renno, Toufic, Manié, Serge N., Chaveroux, Cédric, Ferraro-Peyret, Carole
Vydáno v Metabolites (2021)

Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration–proliferation dichotomy

Autor Bhandari, Deepali, Lopez-Sanchez, Inmaculada, To, Andrew, Lo, I-Chung, Aznar, Nicolas, Leyme, Anthony, Gupta, Vijay, Niesman, Ingrid, Maddox, Adam L., Garcia-Marcos, Mikel, Farquhar, Marilyn G., Ghosh, Pradipta
Vydáno v Proc Natl Acad Sci U S A (2015)

Biochemical, Biophysical and Cellular Techniques to Study the Guanine nucleotide Exchange Factor, GIV/Girdin

Autor Ghosh, Pradipta, Aznar, Nicolas, Swanson, Lee, Lo, I-Chung, Lopez-Sanchez, Inmaculada, Ear, Jason, Rohena, Cristina, Kalogriopoulos, Nicholas, Joosen, Linda, Dunkel, Ying, Sun, Nina, Nguyen, Peter, Bhandari, Deepali
Vydáno v Curr Protoc Chem Biol (2016)

Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

Autor Ear, Jason, Dunkel, Ying, Mittal, Yash, Lim, Blaze B. C., Liu, Lawrence, Holda, Magda K., Nitsche, Ulrich, Barbazán, Jorge, Goel, Ajay, Janssen, Klaus-Peter, Aznar, Nicolas, Ghosh, Pradipta
Vydáno v Sci Rep (2019)

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of Gαi

Autor Kalogriopoulos, Nicholas A., Lopez-Sanchez, Inmaculada, Lin, Changsheng, Ngo, Tony, Midde, Krishna K., Roy, Suchismita, Aznar, Nicolas, Murray, Fiona, Garcia-Marcos, Mikel, Kufareva, Irina, Ghassemian, Majid, Ghosh, Pradipta
Vydáno v Proc Natl Acad Sci U S A (2020)

Increased expression of the thyroid hormone nuclear receptor TRα1 characterizes intestinal tumors with high Wnt activity

Autor Uchuya-Castillo, Joel, Aznar, Nicolas, Frau, Carla, Martinez, Pierre, Le Nevé, Clementine, Marisa, Laetitia, Penalva, Luiz O.F., Laurent-Puig, Pierre, Puisieux, Alain, Scoazec, Jean-Yves, Samarut, Jacques, Ansieau, Stephane, Plateroti, Michelina
Vydáno v Oncotarget (2018)

Daple is a novel non-receptor GEF required for trimeric G protein activation in Wnt signaling

Autor Aznar, Nicolas, Midde, Krishna K, Dunkel, Ying, Lopez-Sanchez, Inmaculada, Pavlova, Yelena, Marivin, Arthur, Barbazán, Jorge, Murray, Fiona, Nitsche, Ulrich, Janssen, Klaus-Peter, Willert, Karl, Goel, Ajay, Abal, Miguel, Garcia-Marcos, Mikel, Ghosh, Pradipta
Vydáno v eLife (2015)

GIV/Girdin activates Gαi and inhibits Gαs via the same motif

Autor Gupta, Vijay, Bhandari, Deepali, Leyme, Anthony, Aznar, Nicolas, Midde, Krishna K., Lo, I-Chung, Ear, Jason, Niesman, Ingrid, López-Sánchez, Inmaculada, Blanco-Canosa, Juan Bautista, von Zastrow, Mark, Garcia-Marcos, Mikel, Farquhar, Marilyn G., Ghosh, Pradipta
Vydáno v Proc Natl Acad Sci U S A (2016)