Cyclin-dependent kinase 5 activates guanine nucleotide exchange factor GIV/Girdin to orchestrate migration–proliferation dichotomy

Signals propagated by receptor tyrosine kinases (RTKs) can drive cell migration and proliferation, two cellular processes that do not occur simultaneously—a phenomenon called “migration–proliferation dichotomy.” We previously showed that epidermal growth factor (EGF) signaling is skewed to favor mig...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Bhandari, Deepali, Lopez-Sanchez, Inmaculada, To, Andrew, Lo, I-Chung, Aznar, Nicolas, Leyme, Anthony, Gupta, Vijay, Niesman, Ingrid, Maddox, Adam L., Garcia-Marcos, Mikel, Farquhar, Marilyn G., Ghosh, Pradipta
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4568279/
https://ncbi.nlm.nih.gov/pubmed/26286990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514157112
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