Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin

A long-standing issue in the field of signal transduction is to understand the cross-talk between receptor tyrosine kinases (RTKs) and heterotrimeric G proteins, two major and distinct signaling hubs that control eukaryotic cell behavior. Although stimulation of many RTKs leads to activation of trim...

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Publicado en:Mol Biol Cell
Autores principales: Lin, Changsheng, Ear, Jason, Midde, Krishna, Lopez-Sanchez, Inmaculada, Aznar, Nicolas, Garcia-Marcos, Mikel, Kufareva, Irina, Abagyan, Ruben, Ghosh, Pradipta
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230624/
https://ncbi.nlm.nih.gov/pubmed/25187647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-05-0978
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