Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors

Previously, Aznar et al., showed that Daple/CCDC88C enables Wnt receptors to transactivate trimeric G-proteins during non-canonical Wnt signaling via a novel G-protein binding and activating (GBA) motif. By doing so, Daple serves two opposing roles; earlier during oncogenesis it suppresses neoplasti...

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Publicat a:Sci Rep
Autors principals: Ear, Jason, Dunkel, Ying, Mittal, Yash, Lim, Blaze B. C., Liu, Lawrence, Holda, Magda K., Nitsche, Ulrich, Barbazán, Jorge, Goel, Ajay, Janssen, Klaus-Peter, Aznar, Nicolas, Ghosh, Pradipta
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6702192/
https://ncbi.nlm.nih.gov/pubmed/31431650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-48420-w
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