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Activation of G proteins by GIV-GEF is a pivot point for insulin resistance and sensitivity
Insulin resistance (IR) is a metabolic disorder characterized by impaired insulin signaling and cellular glucose uptake. The current paradigm for insulin signaling centers upon the insulin receptor (InsR) and its substrate IRS1; the latter is believed to be the sole conduit for postreceptor signalin...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4642855/ https://ncbi.nlm.nih.gov/pubmed/26378251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E15-08-0553 |
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