Potential Relation of Aberrant Proteolysis of Human Protein Tyrosine Kinase 7 (PTK7) chuzhoi by Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) to Congenital Defects

Por Golubkov, Vladislav S., Aleshin, Alexander E., Strongin, Alex Y.
Publicado em 2011

Structural evidence for regulation and specificity of flaviviral proteases and evolution of the Flaviviridae fold

Por Aleshin, Alexander E., Shiryaev, Sergey A., Strongin, Alex Y., Liddington, Robert C.
Publicado em 2007

Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex

Por Aleshin, Alexander E., DiScipio, Richard G., Stec, Boguslaw, Liddington, Robert C.
Publicado em 2012

NS4A regulates the ATPase activity of the NS3 helicase: a novel cofactor role of the non-structural protein NS4A from West Nile virus

Por Shiryaev, Sergey A., Chernov, Andrei V., Aleshin, Alexander E., Shiryaeva, Tatiana N., Strongin, Alex Y.
Publicado em 2009

The acidic sequence of the NS4A cofactor regulates ATP hydrolysis by the HCV NS3 helicase

Por Shiryaev, Sergey A., Chernov, Andrei V., Shiryaeva, Tatiana N., Aleshin, Alexander E., Strongin, Alex Y.
Publicado em 2010

Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein

Por Aoyagi, Mika, Zhai, Dayong, Jin, Chaofang, Aleshin, Alexander E., Stec, Boguslaw, Reed, John C., Liddington, Robert C.
Publicado em 2007

Expression and purification of a two-component flaviviral proteinase resistant to autocleavage at the NS2B-NS3 junction region

Por Shiryaev, Sergey A., Aleshin, Alexander E., Ratnikov, Boris I., Smith, Jeffrey W., Liddington, Robert C., Strongin, Alex Y.
Publicado em 2006

Structure of Complement C6 Suggests a Mechanism for Initiation and Unidirectional, Sequential Assembly of Membrane Attack Complex (MAC)

Por Aleshin, Alexander E., Schraufstatter, Ingrid U., Stec, Boguslaw, Bankston, Laurie A., Liddington, Robert C., DiScipio, Richard G.
Publicado em 2012

Matrix metalloproteinase proteolysis of the mycobacterial HSP65 protein as a potential source of immunogenic peptides in human tuberculosis

Por Shiryaev, Sergey A., Cieplak, Piotr, Aleshin, Alexander E., Sun, Qing, Zhu, Wenhong, Motamedchaboki, Khatereh, Sloutsky, Alexander, Strongin, Alex Y.
Publicado em 2011

The Two-component NS2B-NS3 Proteinase Represses DNA Unwinding Activity of the West Nile Virus NS3 Helicase

Por Chernov, Andrei V., Shiryaev, Sergey A., Aleshin, Alexander E., Ratnikov, Boris I., Smith, Jeffrey W., Liddington, Robert C., Strongin, Alex Y.
Publicado em 2008

Activity, Specificity, and Probe Design for the Smallpox Virus Protease K7L

Por Aleshin, Alexander E., Drag, Marcin, Gombosuren, Naran, Wei, Ge, Mikolajczyk, Jowita, Satterthwait, Arnold C., Strongin, Alex Y., Liddington, Robert C., Salvesen, Guy S.
Publicado em 2012

Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B–NS3 proteinase of West Nile virus

Por SHIRYAEV, Sergey A., RADICHEV, Ilian A., RATNIKOV, Boris I., ALESHIN, Alexander E., GAWLIK, Katarzyna, STEC, Boguslaw, FRISCH, Christian, KNAPPIK, Achim, STRONGIN, Alex Y.
Publicado em 2010

Crystal and Solution Structures of a Prokaryotic M16B Peptidase: an Open and Shut Case

Por Aleshin, Alexander E., Gramatikova, Svetlana, Hura, Gregory L., Bobkov, Andrey, Strongin, Alex Y., Stec, Boguslaw, Tainer, John A., Liddington, Robert C., Smith, Jeffrey W.
Publicado em 2009

Switching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based Mutagenesis

Por Shiryaev, Sergey A., Ratnikov, Boris I., Aleshin, Alexander E., Kozlov, Igor A., Nelson, Nicholas A., Lebl, Michal, Smith, Jeffrey W., Liddington, Robert C., Strongin, Alex Y.
Publicado em 2007

The Wnt/Planar Cell Polarity Protein-tyrosine Kinase-7 (PTK7) Is a Highly Efficient Proteolytic Target of Membrane Type-1 Matrix Metalloproteinase: IMPLICATIONS IN CANCER AND EMBRY...

Por Golubkov, Vladislav S., Chekanov, Alexei V., Cieplak, Piotr, Aleshin, Alexander E., Chernov, Andrei V., Zhu, Wenhong, Radichev, Ilian A., Zhang, Danhua, Dong, P. Duc, Strongin, Alex Y.
Publicado em 2010

Structural and functional diversity of metalloproteinases encoded by the Bacteroides fragilis pathogenicity island

Por Shiryaev, Sergey A., Aleshin, Alexander E., Muranaka, Norihito, Kukreja, Muskan, Routenberg, David A., Remacle, Albert G., Liddington, Robert C., Cieplak, Piotr, Kozlov, Igor A., Strongin, Alex Y.
Publicado em 2014

Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY

Por Rodionova, Irina A., Zuccola, Harmon J., Sorci, Leonardo, Aleshin, Alexander E., Kazanov, Marat D., Ma, Chen-Ting, Sergienko, Eduard, Rubin, Eric J., Locher, Christopher P., Osterman, Andrei L.
Publicado no J Biol Chem (2015)

Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells

Por Rozanov, Dmitri V., Savinov, Alexei Y., Golubkov, Vladislav S., Rozanova, Olga L., Postnova, Tatiana I., Sergienko, Eduard A., Vasile, Stefan, Aleshin, Alexander E., Rega, Michele F., Pellecchia, Maurizio, Strongin, Alex Y.
Publicado em 2009

Internal Cleavages of the Autoinhibitory Prodomain Are Required for Membrane Type 1 Matrix Metalloproteinase Activation, although Furin Cleavage Alone Generates Inactive Proteinase

Por Golubkov, Vladislav S., Cieplak, Piotr, Chekanov, Alexei V., Ratnikov, Boris I., Aleshin, Alexander E., Golubkova, Natalya V., Postnova, Tatiana I., Radichev, Ilian A., Rozanov, Dmitri V., Zhu, Wenhong, Motamedchaboki, Khatereh, Strongin, Alex Y.
Publicado em 2010

TRAIL-Based High Throughput Screening Reveals a Link between TRAIL-Mediated Apoptosis and Glutathione Reductase, a Key Component of Oxidative Stress Response

Por Rozanov, Dmitri, Cheltsov, Anton, Sergienko, Eduard, Vasile, Stefan, Golubkov, Vladislav, Aleshin, Alexander E., Levin, Trevor, Traer, Elie, Hann, Byron, Freimuth, Julia, Alexeev, Nikita, Alekseyev, Max A., Budko, Sergey P, Bächinger, Hans Peter, Spellman, Paul
Publicado no PLoS One (2015)