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Crystal Structure of C5b-6 Suggests Structural Basis for Priming Assembly of the Membrane Attack Complex
The complement membrane attack complex (MAC) forms transmembrane pores in pathogen membranes. The first step in MAC assembly is cleavage of C5 to generate metastable C5b, which forms a stable complex with C6, termed C5b-6. C5b-6 initiates pore formation via the sequential recruitment of homologous p...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3365999/ https://ncbi.nlm.nih.gov/pubmed/22500023 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.361121 |
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