Switching the Substrate Specificity of the Two-Component NS2B-NS3 Flavivirus Proteinase by Structure-Based Mutagenesis

The flavivirus NS2B-NS3(pro)teinase is an essential element in the proteolytic processing of the viral precursor polyprotein and therefore a potential drug target. Recently, crystal structures and substrate preferences of NS2B-NS3pro from Dengue and West Nile viruses (DV and WNV) were determined. We...

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Detalhes bibliográficos
Main Authors: Shiryaev, Sergey A., Ratnikov, Boris I., Aleshin, Alexander E., Kozlov, Igor A., Nelson, Nicholas A., Lebl, Michal, Smith, Jeffrey W., Liddington, Robert C., Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Virus-Cell Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900165/
https://ncbi.nlm.nih.gov/pubmed/17301157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02719-06
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