Mycobacterial Nicotinate Mononucleotide Adenylyltransferase: STRUCTURE, MECHANISM, AND IMPLICATIONS FOR DRUG DISCOVERY

Nicotinate mononucleotide adenylyltransferase NadD is an essential enzyme in the biosynthesis of the NAD cofactor, which has been implicated as a target for developing new antimycobacterial therapies. Here we report the crystal structure of Mycobacterium tuberculosis NadD (MtNadD) at a resolution of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rodionova, Irina A., Zuccola, Harmon J., Sorci, Leonardo, Aleshin, Alexander E., Kazanov, Marat D., Ma, Chen-Ting, Sergienko, Eduard, Rubin, Eric J., Locher, Christopher P., Osterman, Andrei L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4367272/
https://ncbi.nlm.nih.gov/pubmed/25631047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.628016
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