Targeting NAD biosynthesis in bacterial pathogens. Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD

The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based...

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Detalhes bibliográficos
Main Authors: Sorci, Leonardo, Pan, Yongping, Eyobo, Yvonne, Rodionova, Irina, Huang, Nian, Kurnasov, Oleg, Zhong, Shijun, MacKerell, Alexander D., Zhang, Hong, Osterman, Andrei L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770502/
https://ncbi.nlm.nih.gov/pubmed/19716475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.006
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