Targeting NAD biosynthesis in bacterial pathogens. Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD

The emergence of multidrug-resistant pathogens necessitates the search for new antibiotics acting on previously unexplored targets. Nicotinate mononucleotide adenylyltransferase of the NadD family, an essential enzyme of NAD biosynthesis in most bacteria, was selected as a target for structure-based...

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Main Authors: Sorci, Leonardo, Pan, Yongping, Eyobo, Yvonne, Rodionova, Irina, Huang, Nian, Kurnasov, Oleg, Zhong, Shijun, MacKerell, Alexander D., Zhang, Hong, Osterman, Andrei L.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2770502/
https://ncbi.nlm.nih.gov/pubmed/19716475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.07.006
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