Metabolic and Bactericidal Effects of Targeted Suppression of NadD and NadE Enzymes in Mycobacteria

Mycobacterium tuberculosis remains a major cause of death due to the lack of treatment accessibility, HIV coinfection, and drug resistance. Development of new drugs targeting previously unexplored pathways is essential to shorten treatment time and eliminate persistent M. tuberculosis. A promising b...

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Detalhes bibliográficos
Main Authors: Rodionova, Irina A., Schuster, Brian M., Guinn, Kristine M., Sorci, Leonardo, Scott, David A., Li, Xiaoqing, Kheterpal, Indu, Shoen, Carolyn, Cynamon, Michael, Locher, Christopher, Rubin, Eric J., Osterman, Andrei L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Microbiology 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944813/
https://ncbi.nlm.nih.gov/pubmed/24549842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00747-13
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