Engineering a leucine zipper-TRAIL homotrimer with improved cytotoxicity in tumor cells

Successful cancer therapies aim to induce selective apoptosis in neoplastic cells. The current suboptimal efficiency and selectivity drugs have therapeutic limitations and induce concomitant side effects. Recently, novel cancer therapies based on the use of tumor necrosis factor-related apoptosis-in...

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Detalhes bibliográficos
Main Authors: Rozanov, Dmitri V., Savinov, Alexei Y., Golubkov, Vladislav S., Rozanova, Olga L., Postnova, Tatiana I., Sergienko, Eduard A., Vasile, Stefan, Aleshin, Alexander E., Rega, Michele F., Pellecchia, Maurizio, Strongin, Alex Y.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828983/
https://ncbi.nlm.nih.gov/pubmed/19509255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-0202
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