Netupitant and palonosetron trigger NK(1) receptor internalization in NG108-15 cells

Por Thomas, Ajit G., Stathis, Marigo, Rojas, Camilo, Slusher, Barbara S.
Publicado em 2014

Development of a primary microglia screening assay and its use to characterize inhibition of system x(c)(-) by erastin and its analogs

Por Figuera-Losada, Mariana, Thomas, Ajit G., Stathis, Marigo, Stockwell, Brent R., Rojas, Camilo, Slusher, Barbara S.
Publicado no Biochem Biophys Rep (2017)

Incorporation of metabolically stable ketones into a small molecule probe to increase potency and water solubility

Por Larraufie, Marie-Helene, Yang, Wan Seok, Jiang, Elise, Thomas, Ajit G., Slusher, Barbara S., Stockwell, Brent R.
Publicado no Bioorg Med Chem Lett (2015)

Small Molecule Glutaminase Inhibitors Block Glutamate Release from Stimulated Microglia

Por Thomas, Ajit G., O'Driscoll, Cliona M., Bressler, Joseph, Kaufmann, Walter E., Rojas, Camilo J., Slusher, Barbara S.
Publicado em 2013

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of Glutamate Carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

Por Zhang, Zhi, Bassam, Bassam, Thomas, Ajit G., Williams, Monica, Liu, Jinhuan, Nance, Elizabeth, Rojas, Camilo, Slusher, Barbara S., Kannan, Sujatha
Publicado no Neurobiol Dis (2016)

High-Throughput Assay Development for Cystine-Glutamate Antiporter (x(c) (-)) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells

Por Thomas, Ajit G., Sattler, Rita, Tendyke, Karen, Loiacono, Kara A., Hansen, Hans, Sahni, Vishal, Hashizume, Yutaka, Rojas, Camilo, Slusher, Barbara S.
Publicado no PLoS One (2015)

The Antiemetic 5-HT(3) Receptor Antagonist Palonosetron Inhibits Substance P-Mediated Responses In Vitro and In Vivo()

Por Rojas, Camilo, Li, Ying, Zhang, Jie, Stathis, Marigo, Alt, Jesse, Thomas, Ajit G., Cantoreggi, Sergio, Sebastiani, Silvia, Pietra, Claudio, Slusher, Barbara S.
Publicado em 2010

Inhibition of N-acetylated-alpha-Linked-Acidic Dipeptidase (NAALADase) by 2-PMPA Attenuates Cocaine-Induced Relapse in Rats: A NAAG-mGluR2/3-Mediated Mechanism

Por Xi, Zheng-Xiong, Li, Xia, Peng, Xiao-Qing, Li, Jie, Chun, Lauren, Gardner, Eliot L., Thomas, Ajit G., Slusher, Barbara S., Ashby, Charles R.
Publicado em 2009

Synthesis of kojic acid derivatives as secondary binding site probes of D-amino acid oxidase

Por Raje, Mithun, Hin, Niyada, Duvall, Bridget, Ferraris, Dana V., Berry, James F., Thomas, Ajit G., Alt, Jesse, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Publicado em 2013

Kinetic characterization of ebselen, chelerythrine and apomorphine as glutaminase inhibitors

Por Thomas, Ajit G., Rojas, Camilo, Tanega, Cordelle, Shen, Min, Simeonov, Anton, Boxer, Matthew B., Auld, Douglas S., Ferraris, Dana V., Tsukamoto, Takashi, Slusher, Barbara S.
Publicado em 2013

D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog

Por Rojas, Camilo, Alt, Jesse, Ator, Nancy A, Thomas, Ajit G, Wu, Ying, Hin, Niyada, Wozniak, Krystyna, Ferraris, Dana, Rais, Rana, Tsukamoto, Takashi, Slusher, Barbara S
Publicado no Neuropsychopharmacology (2016)

6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d-Amino Acid Oxidase Inhibitors

Por Hin, Niyada, Duvall, Bridget, Ferraris, Dana, Alt, Jesse, Thomas, Ajit G., Rais, Rana, Rojas, Camilo, Wu, Ying, Wozniak, Krystyna M., Slusher, Barbara S., Tsukamoto, Takashi
Publicado no J Med Chem (2015)

Synthesis and SAR of 1-Hydroxy-1H-benzo[d]imidazol-2(3H)-ones as Inhibitors of d-Amino Acid Oxidase

Por Berry, James F., Ferraris, Dana V., Duvall, Bridget, Hin, Niyada, Rais, Rana, Alt, Jesse, Thomas, Ajit G., Rojas, Camilo, Hashimoto, Kenji, Slusher, Barbara S., Tsukamoto, Takashi
Publicado em 2012

Allosteric Glutaminase Inhibitors Based on a 1,4-Di(5-amino-1,3,4-thiadiazol-2-yl)butane Scaffold

Por Zimmermann, Sarah C., Wolf, Emily F., Luu, Andrew, Thomas, Ajit G., Stathis, Marigo, Poore, Brad, Nguyen, Christopher, Le, Anne, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Publicado no ACS Med Chem Lett (2016)

Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease

Por Date, Abhijit A., Rais, Rana, Babu, Taarika, Ortiz, Jairo, Kanvinde, Pranjali, Thomas, Ajit G., Zimmermann, Sarah C., Gadiano, Alexandra J., Halpert, Gilad, Slusher, Barbara S., Ensign, Laura M.
Publicado no J Control Release (2017)

FOLH1/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities

Por Rais, Rana, Jiang, Weiwei, Zhai, Huihong, Wozniak, Krystyna M., Stathis, Marigo, Hollinger, Kristen R., Thomas, Ajit G., Rojas, Camilo, Vornov, James J., Marohn, Michael, Li, Xuhang, Slusher, Barbara S.
Publicado no JCI Insight (2016)

Pharmacokinetics of Oral d-Serine in d-Amino Acid Oxidase Knockout Mice

Por Rais, Rana, Thomas, Ajit G., Wozniak, Krystyna, Wu, Ying, Jaaro-Peled, Hanna, Sawa, Akira, Strick, Christine A., Engle, Sandra J., Brandon, Nicholas J., Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Publicado em 2012

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Por Dixon, Scott J, Patel, Darpan N, Welsch, Matthew, Skouta, Rachid, Lee, Eric D, Hayano, Miki, Thomas, Ajit G, Gleason, Caroline E, Tatonetti, Nicholas P, Slusher, Barbara S, Stockwell, Brent R
Publicado em 2014

Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

Por Ghadge, Ghanashyam D., Slusher, Barbara S., Bodner, Amos, Canto, Mauro Dal, Wozniak, Krystyna, Thomas, Ajit G., Rojas, Camilo, Tsukamoto, Takashi, Majer, Pavel, Miller, Richard J., Monti, Anna Liza, Roos, Raymond P.
Publicado em 2003

Design, synthesis, and pharmacological evaluation of bis-2-(5-phenylacetamido-1,2,4-thiadiazol-2-yl)ethyl sulfide (BPTES) analogs as glutaminase inhibitors

Por Shukla, Krupa, Ferraris, Dana V., Thomas, Ajit G., Stathis, Marigo, Duvall, Bridget, Delahanty, Greg, Alt, Jesse, Rais, Rana, Rojas, Camilo, Gao, Ping, Xiang, Yan, Dang, Chi V., Slusher, Barbara S., Tsukamoto, Takashi
Publicado em 2012