6-Hydroxy-1,2,4-triazine-3,5(2H,4H)-dione Derivatives as Novel d-Amino Acid Oxidase Inhibitors

[Image: see text] A series of 2-substituted 6-hydroxy-1,2,4-triazine-3,5(2H,4H)-dione derivatives were synthesized as inhibitors of d-amino acid oxidase (DAAO). Many compounds in this series were found to be potent DAAO inhibitors, with IC(50) values in the double-digit nanomolar range. The 6-hydrox...

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Veröffentlicht in:J Med Chem
Hauptverfasser: Hin, Niyada, Duvall, Bridget, Ferraris, Dana, Alt, Jesse, Thomas, Ajit G., Rais, Rana, Rojas, Camilo, Wu, Ying, Wozniak, Krystyna M., Slusher, Barbara S., Tsukamoto, Takashi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2015
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5003509/
https://ncbi.nlm.nih.gov/pubmed/26309148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00482
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