D-Amino-Acid Oxidase Inhibition Increases D-Serine Plasma Levels in Mouse But not in Monkey or Dog

D-serine has been shown to improve positive, negative, and cognitive symptoms when used as add-on therapy for the treatment of schizophrenia. However, D-serine has to be administered at high doses to observe clinical effects. This is thought to be due to D-serine undergoing oxidation by D-amino-acid...

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Detalhes bibliográficos
Publicado no:Neuropsychopharmacology
Main Authors: Rojas, Camilo, Alt, Jesse, Ator, Nancy A, Thomas, Ajit G, Wu, Ying, Hin, Niyada, Wozniak, Krystyna, Ferraris, Dana, Rais, Rana, Tsukamoto, Takashi, Slusher, Barbara S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4832022/
https://ncbi.nlm.nih.gov/pubmed/26471255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2015.319
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