Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

Approximately 10% of cases of amyotrophic lateral sclerosis (ALS), a progressive and fatal degeneration that targets motor neurons (MNs), are inherited, and ≈20% of these cases of familial ALS (FALS) are caused by mutations of copper/zinc superoxide dismutase type 1. Glutamate excitotoxicity has bee...

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Detalhes bibliográficos
Main Authors: Ghadge, Ghanashyam D., Slusher, Barbara S., Bodner, Amos, Canto, Mauro Dal, Wozniak, Krystyna, Thomas, Ajit G., Rojas, Camilo, Tsukamoto, Takashi, Majer, Pavel, Miller, Richard J., Monti, Anna Liza, Roos, Raymond P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC170956/
https://ncbi.nlm.nih.gov/pubmed/12876198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530168100
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