Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

Approximately 10% of cases of amyotrophic lateral sclerosis (ALS), a progressive and fatal degeneration that targets motor neurons (MNs), are inherited, and ≈20% of these cases of familial ALS (FALS) are caused by mutations of copper/zinc superoxide dismutase type 1. Glutamate excitotoxicity has bee...

詳細記述

保存先:
書誌詳細
主要な著者: Ghadge, Ghanashyam D., Slusher, Barbara S., Bodner, Amos, Canto, Mauro Dal, Wozniak, Krystyna, Thomas, Ajit G., Rojas, Camilo, Tsukamoto, Takashi, Majer, Pavel, Miller, Richard J., Monti, Anna Liza, Roos, Raymond P.
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 2003
主題:
Biological Sciences
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC170956/
https://ncbi.nlm.nih.gov/pubmed/12876198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530168100
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