Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models

Approximately 10% of cases of amyotrophic lateral sclerosis (ALS), a progressive and fatal degeneration that targets motor neurons (MNs), are inherited, and ≈20% of these cases of familial ALS (FALS) are caused by mutations of copper/zinc superoxide dismutase type 1. Glutamate excitotoxicity has bee...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Ghadge, Ghanashyam D., Slusher, Barbara S., Bodner, Amos, Canto, Mauro Dal, Wozniak, Krystyna, Thomas, Ajit G., Rojas, Camilo, Tsukamoto, Takashi, Majer, Pavel, Miller, Richard J., Monti, Anna Liza, Roos, Raymond P.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2003
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC170956/
https://ncbi.nlm.nih.gov/pubmed/12876198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1530168100
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