Pharmacokinetics and Pharmacodynamics of the Glutamate Carboxypeptidase II Inhibitor 2-MPPA Show Prolonged Alleviation of Neuropathic Pain through an Indirect Mechanism

Glutamate carboxypeptidase II (GCP II) is a therapeutic target in neurologic disorders associated with excessive activation of glutamatergic systems. The potent, orally bioavailable GCP II inhibitor 2-(3-mercaptopropyl) pentanedioic acid (2-MPPA) is effective in preclinical models of diseases where...

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Bibliographic Details
Main Authors: Vornov, James J., Wozniak, Krystyna M., Wu, Ying, Rojas, Camilo, Rais, Rana, Slusher, Barbara S.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2013
Subjects:
Drug Discovery and Translational Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186626/
https://ncbi.nlm.nih.gov/pubmed/23776202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.113.205039
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