δ-Thiolactones as prodrugs of thiol-based glutamate carboxypeptidase II (GCPII) inhibitors

δ-Thiolactones derived from thiol-based glutamate carboxypeptidase II (GCPII) inhibitors were evaluated as prodrugs. In rat liver microsomes, 2-(3-mercaptopropyl)pentanedioic acid (2-MPPA, 1) was gradually produced from 3-(2-oxotetrahydro-thiopyran-3-yl)propionic acid (5), a thiolactone derived from...

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Главные авторы: Ferraris, Dana V., Majer, Pavel, Ni, Chiyou, Slusher, C. Ethan, Rais, Rana, Wu, Ying, Wozniak, Krystyna M., Alt, Jesse, Rojas, Camilo, Slusher, Barbara S., Tsukamoto, Takashi
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3932958/
https://ncbi.nlm.nih.gov/pubmed/24354364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm401703a
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