Inhibition of Glutamate Carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis

Half of all patients with multiple sclerosis (MS) experience cognitive impairment, for which there is no pharmacological treatment. Using magnetic resonance spectroscopy (MRS), we examined metabolic changes in the hippocampi of MS patients, compared the findings to performance on a neurocognitive te...

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Main Authors: Rahn, Kristen A., Watkins, Crystal C., Alt, Jesse, Rais, Rana, Stathis, Marigo, Grishkan, Inna, Crainiceau, Ciprian M., Pomper, Martin G., Rojas, Camilo, Pletnikov, Mikhail V., Calabresi, Peter A., Brandt, Jason, Barker, Peter B., Slusher, Barbara S., Kaplin, Adam I.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3523869/
https://ncbi.nlm.nih.gov/pubmed/23169655
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1209934109
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