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Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
Exchange of extracellular cystine for intracellular glutamate by the antiporter system x(c)(−) is implicated in numerous pathologies. Pharmacological agents that inhibit system x(c)(−) activity with high potency have long been sought, but have remained elusive. In this study, we report that the smal...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054777/ https://ncbi.nlm.nih.gov/pubmed/24844246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02523 |
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