Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Exchange of extracellular cystine for intracellular glutamate by the antiporter system x(c)(−) is implicated in numerous pathologies. Pharmacological agents that inhibit system x(c)(−) activity with high potency have long been sought, but have remained elusive. In this study, we report that the smal...

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Main Authors: Dixon, Scott J, Patel, Darpan N, Welsch, Matthew, Skouta, Rachid, Lee, Eric D, Hayano, Miki, Thomas, Ajit G, Gleason, Caroline E, Tatonetti, Nicholas P, Slusher, Barbara S, Stockwell, Brent R
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2014
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054777/
https://ncbi.nlm.nih.gov/pubmed/24844246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.02523
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