Comparison of the Intracellular Trafficking Itinerary of CTLA-4 Orthologues

Por Kaur, Satdip, Qureshi, Omar S., Sansom, David M.
Publicado em 2013

Confusing signals: Recent progress in CTLA-4 biology

Por Walker, Lucy S.K., Sansom, David M.
Publicado no Trends Immunol (2015)

Normal human pregnancy is associated with an elevation in the immune suppressive CD25(+) CD4(+) regulatory T-cell subset

Por Somerset, David A, Zheng, Yong, Kilby, Mark D, Sansom, David M, Drayson, Mark T
Publicado em 2004

Acquisition of suppressive function by activated human CD4(+) CD25(-) T cells is associated with the expression of CTLA-4 not FoxP3

Por Zheng, Yong, Manzotti, Claire N., Burke, Fiona, Dussably, Laure, Qureshi, Omar, Walker, Lucy SK, Sansom, David M.
Publicado em 2008

1,25(OH)(2)D(3) Promotes the Efficacy of CD28 Costimulation Blockade by Abatacept

Por Gardner, David H., Jeffery, Louisa E., Soskic, Blagoje, Briggs, Zoe, Hou, Tie Zheng, Raza, Karim, Sansom, David M.
Publicado no J Immunol (2015)

A Transendocytosis model of CTLA-4 function predicts its suppressive behaviour on regulatory T cells

Por Hou, Tie Zheng, Qureshi, Omar S., Wang, Chun Jing, Baker, Jennifer, Young, Stephen P., Walker, Lucy S.K., Sansom, David M.
Publicado no J Immunol (2015)

Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

Por Jeffery, Louisa E., Qureshi, Omar S., Gardner, David, Hou, Tie Z., Briggs, Zoe, Soskic, Blagoje, Baker, Jennifer, Raza, Karim, Sansom, David M.
Publicado no PLoS One (2015)

Availability of 25-hydroxyvitamin D(3) to antigen presenting cells controls the balance between regulatory and inflammatory T cell responses

Por Jeffery, Louisa E., Wood, Alice M., Qureshi, Omar S, Hou, Tie Zheng, Gardner, David, Briggs, Zoe, Kaur, Satdip, Raza, Karim, Sansom, David M.
Publicado em 2012

Cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells()

Por Wang, Chun Jing, Kenefeck, Rupert, Wardzinski, Lukasz, Attridge, Kesley, Manzotti, Claire, Schmidt, Emily M., Qureshi, Omar S., Sansom, David M., Walker, Lucy S.K.
Publicado em 2012

CTLA-4 controls follicular helper T-cell differentiation by regulating the strength of CD28 engagement

Por Wang, Chun Jing, Heuts, Frank, Ovcinnikovs, Vitalijs, Wardzinski, Lukasz, Bowers, Chantelle, Schmidt, Emily M., Kogimtzis, Alexandros, Kenefeck, Rupert, Sansom, David M., Walker, Lucy S. K.
Publicado no Proc Natl Acad Sci U S A (2015)

Loss of CD28 Expression by Liver-Infiltrating T Cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis

Por Liaskou, Evaggelia, Jeffery, Louisa E., Trivedi, Palak J., Reynolds, Gary M., Suresh, Shankar, Bruns, Tony, Adams, David H., Sansom, David M., Hirschfield, Gideon M.
Publicado no Gastroenterology (2014)

1,25-dihydroxyvitamin D(3) and interleukin-2 combine to inhibit T cell production of inflammatory cytokines and promote development of regulatory T cells expressing CTLA-4 and FoxP...

Por Jeffery, Louisa E, Burke, Fiona, Mura, Manuela, Zheng, Yong, Qureshi, Omar S, Hewison, Martin, Walker, Lucy S.K., Lammas, David A, Raza, Karim, Sansom, David M
Publicado em 2009

Low-level Hypermutation in T Cell–independent Germinal Centers Compared with High Mutation Rates Associated with T Cell–dependent Germinal Centers

Por Toellner, Kai-Michael, Jenkinson, William E., Taylor, Dale R., Khan, Mahmood, Sze, Daniel M.-Y., Sansom, David M., Vinuesa, Carola G., MacLennan, Ian C.M.
Publicado em 2002

Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

Por Qureshi, Omar S., Kaur, Satdip, Hou, Tie Zheng, Jeffery, Louisa E., Poulter, Natalie S., Briggs, Zoe, Kenefeck, Rupert, Willox, Anna K., Royle, Stephen J., Rappoport, Joshua Z., Sansom, David M.
Publicado em 2012

Follicular helper T cell signature in type 1 diabetes

Por Kenefeck, Rupert, Wang, Chun Jing, Kapadi, Tauseef, Wardzinski, Lukasz, Attridge, Kesley, Clough, Louise E., Heuts, Frank, Kogimtzis, Alexandros, Patel, Sapna, Rosenthal, Miranda, Ono, Masahiro, Sansom, David M., Narendran, Parth, Walker, Lucy S.K.
Publicado no J Clin Invest (2014)

Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4

Por Qureshi, Omar S., Zheng, Yong, Nakamura, Kyoko, Attridge, Kesley, Manzotti, Claire, Schmidt, Emily M., Baker, Jennifer, Jeffery, Louisa E., Kaur, Satdip, Briggs, Zoe, Hou, Tie Z., Futter, Clare E., Anderson, Graham, Walker, Lucy S.K., Sansom, David M.
Publicado em 2011

Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations

Por Hou, Tie Zheng, Verma, Nisha, Wanders, Jennifer, Kennedy, Alan, Soskic, Blagoje, Janman, Daniel, Halliday, Neil, Rowshanravan, Behzad, Worth, Austen, Qasim, Waseem, Baxendale, Helen, Stauss, Hans, Seneviratne, Suranjith, Neth, Olaf, Olbrich, Peter, Hambleton, Sophie, Arkwright, Peter D., Burns, Siobhan O., Walker, Lucy S. K., Sansom, David M.
Publicado no Blood (2017)

Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS)

Por Dancer, Rachel C A, Parekh, Dhruv, Lax, Sian, D'Souza, Vijay, Zheng, Shengxing, Bassford, Chris R, Park, Daniel, Bartis, D G, Mahida, Rahul, Turner, Alice M, Sapey, Elizabeth, Wei, Wenbin, Naidu, Babu, Stewart, Paul M, Fraser, William D, Christopher, Kenneth B, Cooper, Mark S, Gao, Fang, Sansom, David M, Martineau, Adrian R, Perkins, Gavin D, Thickett, David R
Publicado no Thorax (2015)

Autosomal-dominant immune dysregulation syndrome in humans with CTLA4 mutations

Por Schubert, Desirée, Bode, Claudia, Kenefeck, Rupert, Hou, Tie Zheng, Wing, James B., Kennedy, Alan, Bulashevska, Alla, Petersen, Britt-Sabina, Schäffer, Alejandro A., Grüning, Björn A., Unger, Susanne, Frede, Natalie, Baumann, Ulrich, Witte, Torsten, Schmidt, Reinhold E., Dueckers, Gregor, Niehues, Tim, Seneviratne, Suranjith, Kanariou, Maria, Speckmann, Carsten, Ehl, Stephan, Rensing-Ehl, Anne, Warnatz, Klaus, Rakhmanov, Mirzokhid, Thimme, Robert, Hasselblatt, Peter, Emmerich, Florian, Cathomen, Toni, Backofen, Rolf, Fisch, Paul, Seidl, Maximilian, May, Annette, Schmitt-Graeff, Annette, Ikemizu, Shinji, Salzer, Ulrich, Franke, Andre, Sakaguchi, Shimon, Walker, Lucy S.K., Sansom, David M., Grimbacher, Bodo
Publicado no Nat Med (2014)