Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation

CTLA-4 is one of the most important negative regulators of the T cell immune response. However, the subcellular distribution of CTLA-4 is unusual for a receptor that interacts with cell surface transmembrane ligands in that CTLA-4 is rapidly internalized from the plasma membrane. It has been propose...

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Detalhes bibliográficos
Main Authors: Qureshi, Omar S., Kaur, Satdip, Hou, Tie Zheng, Jeffery, Louisa E., Poulter, Natalie S., Briggs, Zoe, Kenefeck, Rupert, Willox, Anna K., Royle, Stephen J., Rappoport, Joshua Z., Sansom, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3308817/
https://ncbi.nlm.nih.gov/pubmed/22262842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.304329
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