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Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4
CTLA-4 is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 also shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocy...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2011
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3198051/ https://ncbi.nlm.nih.gov/pubmed/21474713 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1202947 |
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