Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4

CTLA-4 is an essential negative regulator of T cell immune responses whose mechanism of action is the subject of debate. CTLA-4 also shares two ligands (CD80 and CD86) with a stimulatory receptor, CD28. Here we show that CTLA-4 can capture its ligands from opposing cells by a process of trans-endocy...

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Autori principali: Qureshi, Omar S., Zheng, Yong, Nakamura, Kyoko, Attridge, Kesley, Manzotti, Claire, Schmidt, Emily M., Baker, Jennifer, Jeffery, Louisa E., Kaur, Satdip, Briggs, Zoe, Hou, Tie Z., Futter, Clare E., Anderson, Graham, Walker, Lucy S.K., Sansom, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3198051/
https://ncbi.nlm.nih.gov/pubmed/21474713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1202947
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