Cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells()

The CTLA-4 pathway is a key regulator of T cell activation and a critical failsafe against autoimmunity. While early models postulated that CTLA-4 transduced a negative signal, in vivo evidence suggests that CTLA-4 functions in a cell-extrinsic manner. That multiple cell-intrinsic mechanisms have be...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Wang, Chun Jing, Kenefeck, Rupert, Wardzinski, Lukasz, Attridge, Kesley, Manzotti, Claire, Schmidt, Emily M., Qureshi, Omar S., Sansom, David M., Walker, Lucy S.K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442233/
https://ncbi.nlm.nih.gov/pubmed/22753931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200972
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