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Cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells()
The CTLA-4 pathway is a key regulator of T cell activation and a critical failsafe against autoimmunity. While early models postulated that CTLA-4 transduced a negative signal, in vivo evidence suggests that CTLA-4 functions in a cell-extrinsic manner. That multiple cell-intrinsic mechanisms have be...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3442233/ https://ncbi.nlm.nih.gov/pubmed/22753931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200972 |
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