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Acquisition of suppressive function by activated human CD4(+) CD25(-) T cells is associated with the expression of CTLA-4 not FoxP3

The role of CTLA-4 in Regulatory T cell (Treg) function is not well understood. We have examined the role of CTLA-4 and its relationship with the transcription factor FoxP3 using a model of Treg induction in human peripheral blood. Activation of human CD4(+)CD25(-) T cells resulted in the appearance...

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Bibliografiske detaljer
Main Authors: Zheng, Yong, Manzotti, Claire N., Burke, Fiona, Dussably, Laure, Qureshi, Omar, Walker, Lucy SK, Sansom, David M.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2758479/
https://ncbi.nlm.nih.gov/pubmed/18641304
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