Vitamin D Antagonises the Suppressive Effect of Inflammatory Cytokines on CTLA-4 Expression and Regulatory Function

The immune suppressive protein CTLA-4 is constitutively expressed by Tregs and induced in effector T cells upon activation. Its crucial role in adaptive immunity is apparent from the fatal autoimmune pathology seen in CTLA-4 knockout mice. However, little is known regarding factors that regulate CTL...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Jeffery, Louisa E., Qureshi, Omar S., Gardner, David, Hou, Tie Z., Briggs, Zoe, Soskic, Blagoje, Baker, Jennifer, Raza, Karim, Sansom, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2015
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489761/
https://ncbi.nlm.nih.gov/pubmed/26134669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131539
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