Loss of CD28 Expression by Liver-Infiltrating T Cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis

BACKGROUND & AIMS: T-cell–mediated biliary injury is a feature of primary sclerosing cholangitis (PSC). We studied the roles of CD28(-) T cells in PSC and their regulation by vitamin D. METHODS: Peripheral and liver-infiltrating mononuclear cells were isolated from blood or fresh liver tissue. W...

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Publicado no:Gastroenterology
Main Authors: Liaskou, Evaggelia, Jeffery, Louisa E., Trivedi, Palak J., Reynolds, Gary M., Suresh, Shankar, Bruns, Tony, Adams, David H., Sansom, David M., Hirschfield, Gideon M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4961260/
https://ncbi.nlm.nih.gov/pubmed/24726754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2014.04.003
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