Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals

The CD28 locus is associated with susceptibility to a variety of autoimmune and immune-mediated inflammatory diseases including primary sclerosing cholangitis (PSC). Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could maintain CD28 expression. Here, we asse...

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Publicado no:Sci Rep
Main Authors: Liaskou, Evaggelia, Jeffery, Louisa, Chanouzas, Dimitrios, Soskic, Blagoje, Seldin, Michael F., Harper, Lorraine, Sansom, David, Hirschfield, Gideon M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5550460/
https://ncbi.nlm.nih.gov/pubmed/28794437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07967-2
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