Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations

Heterozygous CTLA-4 deficiency has been reported as a monogenic cause of common variable immune deficiency with features of immune dysregulation. Direct mutation in CTLA-4 leads to defective regulatory T-cell (Treg) function associated with impaired ability to control levels of the CTLA-4 ligands, C...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Hou, Tie Zheng, Verma, Nisha, Wanders, Jennifer, Kennedy, Alan, Soskic, Blagoje, Janman, Daniel, Halliday, Neil, Rowshanravan, Behzad, Worth, Austen, Qasim, Waseem, Baxendale, Helen, Stauss, Hans, Seneviratne, Suranjith, Neth, Olaf, Olbrich, Peter, Hambleton, Sophie, Arkwright, Peter D., Burns, Siobhan O., Walker, Lucy S. K., Sansom, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438243/
https://ncbi.nlm.nih.gov/pubmed/28159733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-745174
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