Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations

Heterozygous CTLA-4 deficiency has been reported as a monogenic cause of common variable immune deficiency with features of immune dysregulation. Direct mutation in CTLA-4 leads to defective regulatory T-cell (Treg) function associated with impaired ability to control levels of the CTLA-4 ligands, C...

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Bibliografische gegevens
Gepubliceerd in:Blood
Hoofdauteurs: Hou, Tie Zheng, Verma, Nisha, Wanders, Jennifer, Kennedy, Alan, Soskic, Blagoje, Janman, Daniel, Halliday, Neil, Rowshanravan, Behzad, Worth, Austen, Qasim, Waseem, Baxendale, Helen, Stauss, Hans, Seneviratne, Suranjith, Neth, Olaf, Olbrich, Peter, Hambleton, Sophie, Arkwright, Peter D., Burns, Siobhan O., Walker, Lucy S. K., Sansom, David M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2017
Onderwerpen:
Immunobiology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438243/
https://ncbi.nlm.nih.gov/pubmed/28159733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-745174
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