Identifying functional defects in patients with immune dysregulation due to LRBA and CTLA-4 mutations

Heterozygous CTLA-4 deficiency has been reported as a monogenic cause of common variable immune deficiency with features of immune dysregulation. Direct mutation in CTLA-4 leads to defective regulatory T-cell (Treg) function associated with impaired ability to control levels of the CTLA-4 ligands, C...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Blood
Huvudupphovsmän: Hou, Tie Zheng, Verma, Nisha, Wanders, Jennifer, Kennedy, Alan, Soskic, Blagoje, Janman, Daniel, Halliday, Neil, Rowshanravan, Behzad, Worth, Austen, Qasim, Waseem, Baxendale, Helen, Stauss, Hans, Seneviratne, Suranjith, Neth, Olaf, Olbrich, Peter, Hambleton, Sophie, Arkwright, Peter D., Burns, Siobhan O., Walker, Lucy S. K., Sansom, David M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2017
Ämnen:
Immunobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5438243/
https://ncbi.nlm.nih.gov/pubmed/28159733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-10-745174
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk