Characterization of CTLA4 Trafficking and Implications for Its Function

CTLA4 is an essential negative regulator of T-cell immune responses and a key checkpoint regulating autoimmunity and antitumor responses. Genetic mutations resulting in quantitative defects in the CTLA4 pathway are also associated with the development of immune dysregulation syndromes in humans. It...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: Khailaie, Sahamoddin, Rowshanravan, Behzad, Robert, Philippe A., Waters, Erin, Halliday, Neil, Badillo Herrera, Jesus David, Walker, Lucy S.K., Sansom, David M., Meyer-Hermann, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2018
Assuntos:
Cell Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6170599/
https://ncbi.nlm.nih.gov/pubmed/30219287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.08.020
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