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A Transendocytosis model of CTLA-4 function predicts its suppressive behaviour on regulatory T cells
Manipulation of the CD28/CTLA-4 pathway is at the heart of a number of immunomodulatory approaches used in both autoimmunity and cancer. Whilst it is clear that CTLA-4 is a critical regulator of T cell responses, the immunological contexts in which CTLA-4 controls immune responses are not well defin...
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| Publicado en: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4522736/ https://ncbi.nlm.nih.gov/pubmed/25632005 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401876 |
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