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A Transendocytosis model of CTLA-4 function predicts its suppressive behaviour on regulatory T cells

Manipulation of the CD28/CTLA-4 pathway is at the heart of a number of immunomodulatory approaches used in both autoimmunity and cancer. Whilst it is clear that CTLA-4 is a critical regulator of T cell responses, the immunological contexts in which CTLA-4 controls immune responses are not well defin...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Hou, Tie Zheng, Qureshi, Omar S., Wang, Chun Jing, Baker, Jennifer, Young, Stephen P., Walker, Lucy S.K., Sansom, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4522736/
https://ncbi.nlm.nih.gov/pubmed/25632005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401876
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