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CTLA-4 mediated transendocytosis of co-stimulatory molecules primarily targets migratory dendritic cells
CTLA-4 is a critical negative regulator of the immune system and a major target for immunotherapy. Yet precisely how it functions in vivo to maintain immune homeostasis is not clear. As a highly endocytic molecule, CTLA-4 can capture costimulatory ligands from opposing cells by a process of transend...
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| Publié dans: | Sci Immunol |
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| Auteurs principaux: | , , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6570622/ https://ncbi.nlm.nih.gov/pubmed/31152091 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw0902 |
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