Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes

Follicular helper T cells (Tfh) are implicated in type 1 diabetes (T1D) and their development has been linked to CD28 costimulation. We tested whether Tfh were decreased by costimulation blockade using the CTLA-4-Ig fusion protein (Abatacept) in a mouse model of diabetes and in individuals with new...

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Publicado no:Nat Immunol
Main Authors: Edner, Natalie M., Heuts, Frank, Thomas, Niclas, Wang, Chun Jing, Petersone, Lina, Kenefeck, Rupert, Kogimtzis, Alexandros, Ovcinnikovs, Vitalijs, Ross, Ellen M., Ntavli, Elisavet, Elfaki, Yassin, Eichmann, Martin, Baptista, Roman, Ambery, Philip, Jermutus, Lutz, Peakman, Mark, Rosenthal, Miranda, Walker, Lucy S.K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7610476/
https://ncbi.nlm.nih.gov/pubmed/32747817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0744-z
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