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Follicular helper T cell profiles predict response to costimulation blockade in type 1 diabetes
Follicular helper T cells (Tfh) are implicated in type 1 diabetes (T1D) and their development has been linked to CD28 costimulation. We tested whether Tfh were decreased by costimulation blockade using the CTLA-4-Ig fusion protein (Abatacept) in a mouse model of diabetes and in individuals with new...
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| Опубликовано в: : | Nat Immunol |
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| Главные авторы: | , , , , , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2020
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7610476/ https://ncbi.nlm.nih.gov/pubmed/32747817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-020-0744-z |
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