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CTLA-4 mediated transendocytosis of co-stimulatory molecules primarily targets migratory dendritic cells

CTLA-4 is a critical negative regulator of the immune system and a major target for immunotherapy. Yet precisely how it functions in vivo to maintain immune homeostasis is not clear. As a highly endocytic molecule, CTLA-4 can capture costimulatory ligands from opposing cells by a process of transend...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Immunol
मुख्य लेखकों: Ovcinnikovs, Vitalijs, Ross, Ellen M., Petersone, Lina, Edner, Natalie M., Heuts, Frank, Ntavli, Elisavet, Kogimtzis, Alexandros, Kennedy, Alan, Wang, Chun Jing, Bennett, Clare L., Sansom, David M., Walker, Lucy S.K.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570622/
https://ncbi.nlm.nih.gov/pubmed/31152091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw0902
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