CTLA-4 mediated transendocytosis of co-stimulatory molecules primarily targets migratory dendritic cells

CTLA-4 is a critical negative regulator of the immune system and a major target for immunotherapy. Yet precisely how it functions in vivo to maintain immune homeostasis is not clear. As a highly endocytic molecule, CTLA-4 can capture costimulatory ligands from opposing cells by a process of transend...

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Veröffentlicht in:Sci Immunol
Hauptverfasser: Ovcinnikovs, Vitalijs, Ross, Ellen M., Petersone, Lina, Edner, Natalie M., Heuts, Frank, Ntavli, Elisavet, Kogimtzis, Alexandros, Kennedy, Alan, Wang, Chun Jing, Bennett, Clare L., Sansom, David M., Walker, Lucy S.K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6570622/
https://ncbi.nlm.nih.gov/pubmed/31152091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aaw0902
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