Identification of Potential Drug Targets in <i>Helicobacter pylori</i> Using In Silico Subtractive Proteomics Approaches and Their Possible Inhibition through Drug Repurposing

Por Kareem A. Ibrahim, Omneya M. Helmy, Mona T. Kashef, Tharwat R. Elkhamissy, Mohammed A. Ramadan
Publicado em 2020-09-01

A Small Molecule Screen in Stem Cell-derived Motor Neurons Identifies a Kinase Inhibitor as a Candidate Therapeutic for ALS

Por Yang, Yin M., Gupta, Shailesh K., Kim, Kevin J., Powers, Berit E., Cerqueira, Antonio, Wainger, Brian J., Ngo, Hien D., Rosowski, Kathryn A., Schein, Pamela A., Ackeifi, Courtney A., Arvanites, Anthony C., Davidow, Lance S., Woolf, Clifford J., Rubin, Lee L.
Publicado em 2013

New Classes of Alanine Racemase Inhibitors Identified by High-Throughput Screening Show Antimicrobial Activity against Mycobacterium tuberculosis

Por Anthony, Karen G., Strych, Ulrich, Yeung, Kacheong R., Shoen, Carolyn S., Perez, Oriana, Krause, Kurt L., Cynamon, Michael H., Aristoff, Paul A., Koski, Raymond A.
Publicado em 2011

Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors

Por Nath, Abhinav, Zientek, Michael A., Burke, Benjamin J., Jiang, Ying, Atkins, William M.
Publicado em 2010

Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1

Por Abulwerdi, Fardokht A., Xu, Wenbo, Ageeli, Abeer A., Yonkunas, Michael J., Arun, Gayatri, Nam, Hyeyeon, Schneekloth, John S., Dayie, Theodore Kwaku, Spector, David, Baird, Nathan, Le Grice, Stuart F. J.
Publicado no ACS Chem Biol (2019)

If Birds Have Sesamoid Bones, Do Blackbirds Have Sesamoid Bones? The Modification Effect With Known Compound Words

Por Spalding, Thomas L., Gagné, Christina L., Nisbet, Kelly A., Chamberlain, Jenna M., Libben, Gary
Publicado no Front Psychol (2019)

Pyramidamycins A-D and 3-Hydroxyquinoline-2-carboxamide; Cytotoxic Benzamides from Streptomyces sp. DGC1

Por Shaaban, Khaled A., Shepherd, Micah D., Ahmed, Tamer A., Nybo, S. Eric, Leggas, Markos, Rohr, Jürgen
Publicado em 2012

New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2)

Por Ribeiro, Carlos J. A., Kankanala, Jayakanth, Shi, Ke, Kurahashi, Kayo, Kiselev, Evgeny, Ravji, Azhar, Pommier, Yves, Aihara, Hideki, Wang, Zhengqiang
Publicado no Eur J Pharm Sci (2018)

Membrane activity profiling of small molecule B. subtilis growth inhibitors utilizing novel duel-dye fluorescence assay

Por McAuley, S., Huynh, A., Czarny, T. L., Brown, E. D., Nodwell, J. R.
Publicado no Medchemcomm (2018)

Search for Cell Motility and Angiogenesis Inhibitors with Potential Anticancer Activity: Beauvericin and Other Constituents of Two Endophytic Strains of Fusarium oxysporum

Por Zhan, Jixun, Burns, Anna M., Liu, Manping X., Faeth, Stanley H., Gunatilaka, A. A. Leslie
Publicado em 2007

Novel Anti-Campylobacter Compounds Identified Using High Throughput Screening of a Pre-selected Enriched Small Molecules Library

Por Kumar, Anand, Drozd, Mary, Pina-Mimbela, Ruby, Xu, Xiulan, Helmy, Yosra A., Antwi, Janet, Fuchs, James R., Nislow, Corey, Templeton, Jillian, Blackall, Patrick J., Rajashekara, Gireesh
Publicado no Front Microbiol (2016)

Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α

Por Thorne, Curtis A, Hanson, Alison J, Schneider, Judsen, Tahinci, Emilios, Orton, Darren, Cselenyi, Christopher S, Jernigan, Kristin K, Meyers, Kelly C, Hang, Brian I, Waterson, Alex G, Kim, Kwangho, Melancon, Bruce, Ghidu, Victor P, Sulikowski, Gary A, LaFleur, Bonnie, Salic, Adrian, Lee, Laura A, Miller, David M, Lee, Ethan
Publicado em 2010

Epigenetics of breast cancer: modifying role of environmental and bioactive food compounds

Por Romagnolo, Donato F., Daniels, Kevin D., Grunwald, Jonathan T., Ramos, Stephan A., Propper, Catherine R., Selmin, Ornella I.
Publicado no Mol Nutr Food Res (2016)

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses

Por Dančík, Vlado, Carrel, Hyman, Bodycombe, Nicole E., Seiler, Kathleen Petri, Fomina-Yadlin, Dina, Kubicek, Stefan T., Hartwell, Kimberly, Shamji, Alykhan F., Wagner, Bridget K., Clemons, Paul A.
Publicado no J Biomol Screen (2014)

In Silico Mechanistic Profiling to Probe Small Molecule Binding to Sulfotransferases

Por Martiny, Virginie Y., Carbonell, Pablo, Lagorce, David, Villoutreix, Bruno O., Moroy, Gautier, Miteva, Maria A.
Publicado em 2013

A small molecule that binds and inhibits the ETV1 transcription factor oncoprotein

Por Pop, Marius S, Stransky, Nicolas, Garvie, Colin W, Theurillat, Jean-Philippe, Lewis, Timothy A, Zhong, Cheng, Culyba, Elizabeth K, Lin, Fallon, Daniels, Douglas S, Pagliarini, Raymond, Ronco, Lucienne, Koehler, Angela N, Garraway, Levi A
Publicado em 2014

Activation of EGFR by small compounds through coupling the generation of hydrogen peroxide to stable dimerization of Cu/Zn SOD1

Por Sakanyan, Vehary, Hulin, Philippe, Alves de Sousa, Rodolphe, Silva, Viviane A. O., Hambardzumyan, Artur, Nedellec, Steven, Tomasoni, Christophe, Logé, Cédric, Pineau, Charles, Roussakis, Christos, Fleury, Fabrice, Artaud, Isabelle
Publicado no Sci Rep (2016)

Tripolin A, a Novel Small-Molecule Inhibitor of Aurora A Kinase, Reveals New Regulation of HURP's Distribution on Microtubules

Por Kesisova, Iliana A., Nakos, Konstantinos C., Tsolou, Avgi, Angelis, Dimitrios, Lewis, Joe, Chatzaki, Aikaterini, Agianian, Bogos, Giannis, Athanassios, Koffa, Maria D.
Publicado em 2013

Bioactive Secondary Metabolites from Acid Mine Waste Extremophiles

Por Stierle, Andrea A., Stierle, Donald B.
Publicado no Nat Prod Commun (2014)

Development of a Comprehensive, Validated Pharmacophore Hypothesis for Anthrax Toxin Lethal Factor...

Por Chiu, Ting-Lan, Amin, Elizabeth A.
Publicado em 2012