N-Aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a Novel Class of Antitumor Agents Targeting the Colchicine Site on Tubulin

Por Wang, Xiao-Feng, Wang, Sheng-Biao, Ohkoshi, Emika, Wang, Li-Ting, Hamel, Ernest, Qian, Keduo, Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Xie, Lan
Publicado em 2013

Syntheses of novel high affinity ligands for opioid receptors

Por Wentland, Mark P., Lou, Rongliang, Lu, Qun, Bu, Yigong, Denhardt, Christoph, Jin, Jin, Ganorkar, Rakesh, VanAlstine, Melissa A., Guo, Chengyun, Cohen, Dana J., Bidlack, Jean M.
Publicado em 2009

Himbacine-Derived Thrombin Receptor Antagonists: C(7)-Spirocyclic Analogues of Vorapaxar

Por Chelliah, Mariappan V., Eagen, Keith, Guo, Zhuyan, Chackalamannil, Samuel, Xia, Yan, Tsai, Hsingan, Greenlee, William J., Ahn, Ho-Sam, Kurowski, Stan, Boykow, George, Hsieh, Yunsheng, Chintala, Madhu
Publicado em 2014

Natural products and morphogenic activity of γ-Proteobacteria associated with the marine hydroid polyp Hydractinia echinata

Por Guo, Huijuan, Rischer, Maja, Sperfeld, Martin, Weigel, Christiane, Menzel, Klaus Dieter, Clardy, Jon, Beemelmanns, Christine
Publicado no Bioorg Med Chem (2017)

Magnetically Aligned Bicelles to Study the Orientation of Lipophilic Ligands in Membrane Bilayers

Por Guo, Jianxin, Yang, De-Ping, Chari, Ravi, Tian, Xiaoyu, Pavlopoulos, Spiro, Lu, Dai, Makriyannis, Alexandros
Publicado em 2008

Conformationally constrained analogues of 2-arachidonoylglycerol

Por Vadivel, Subramanian K., Vardarajan, Sundararaman, Duclos, Richard I., Wood, JodiAnne T., Guo, Jianxin, Makriyannis, Alexandros
Publicado em 2007

2,4-Diamino-5-methyl-6-substituted Arylthio-furo[2,3-d]pyrimidines as Novel Classical and Nonclassical Antifolates as Potential Dual Thymidylate Synthase and Dihydrofolate Reductas...

Por Gangjee, Aleem, Jain, Hiteshkumar D., Phan, Jaclyn, Guo, Xin, Queener, Sherry F., Kisliuk, Roy L.
Publicado em 2009

Structure-Based Scaffold Repurposing for G Protein-Coupled Receptors: Transformation of Adenosine Derivatives into 5HT(2B)/5HT(2C) Serotonin Receptor Antagonists

Por Tosh, Dilip K., Ciancetta, Antonella, Warnick, Eugene, Crane, Steven, Gao, Zhan-Guo, Jacobson, Kenneth A.
Publicado no J Med Chem (2016)

Analysis of nine compounds from Alpinia oxyphylla fruit at different harvest time using UFLC-MS/MS and an extraction method optimized by orthogonal design

Por Li, Yong-Hui, Chen, Feng, Wang, Jun-fang, Wang, Yong, Zhang, Jun-Qing, Guo, Tao
Publicado em 2013

Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions

Por Kou, Liang, Wang, Mei-Juan, Wang, Li-Ting, Zhao, Xiao-Bo, Nan, Xiang, Yang, Liu, Liu, Ying-Qian, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Publicado em 2014

Design, Synthesis and Cytotoxic Activity of Novel Sulfonylurea Derivatives of Podophyllotoxin

Por Zhang, Zhi-Jun, Tian, Jing, Wang, Li-Ting, Wang, Mei-Juan, Nan, Xiang, Yang, Liu, Liu, Ying-Qian, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Publicado em 2013

Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-κB pathways

Por Lin, Jau-Chen, Yang, Shuenn-Chen, Hong, Tse-Ming, Yu, Sung-Liang, Shi, Qian, Wei, Linyi, Chen, Hsuan-Yu, Yang, Pan-Chyr, Lee, Kuo-Hsiung
Publicado em 2009

Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2′-monomethyl-4-methyl- and 1′-thia-4-methyl-(3′R,4′R)-3′,4′-di-O-(S)-camphanoyl-(+)-cis-khel...

Por Xu, Shi-Qing, Yan, Xin, Chen, Ying, Xia, Peng, Qian, Keduo, Yu, Donglei, Xia, Yi, Yang, Zheng-Yu, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Publicado em 2010

Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents

Por Dong, Yizhou, Nakagawa-Goto, Kyoko, Lai, Chin-Yu, Kim, Yoon, Morris-Natschke, Susan L., Lee, Eva Y.-H. P., Bastow, Kenneth F., Lee, Kuo-Hsiung
Publicado em 2010

A New Highly Reactive and Low Lipophilicity Fluorine-18 Labeled Tetrazine Derivative for Pretargeted PET Imaging

Por Keinänen, Outi, Li, Xiang-Guo, Chenna, Naveen K., Lumen, Dave, Ott, Jennifer, Molthoff, Carla F. M., Sarparanta, Mirkka, Helariutta, Kerttuli, Vuorinen, Tapani, Windhorst, Albert D., Airaksinen, Anu J.
Publicado no ACS Med Chem Lett (2015)

First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents

Por Lin, An-Shen, Nakagawa-Goto, Kyoko, Chang, Fang-Rong, Yu, Donglei, Morris-Natschke, Susan L., Wu, Chin-Chung, Chen, Shu-Li, Wu, Yang-Chang, Lee, Kuo-Hsiung
Publicado em 2007

Alkaloids from Oxytropis ochrocephala and Antiproliferative Activity of Sophoridine Derivatives Against Cancer Cell Lines

Por Tan, Cheng-jian, Zhao, Yu, Goto, Masuo, Hsieh, Kan-Yen, Yang, Xiao-ming, Morris-Natschke, Susan L., Liu, Li-na, Zhao, Bao-yu, Lee, Kuo-Hsiung
Publicado no Bioorg Med Chem Lett (2015)

Diarylaniline Derivatives as a Distinct Class of HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Por Qin, Bingjie, Jiang, Xingkai, Lu, Hong, Tian, Xingtao, Barbault, Florent, Huang, Li, Qian, Keduo, Chen, Chin-Ho, Huang, Rong, Jiang, Shibo, Lee, Kuo-Hsiung, Xie, Lan
Publicado em 2010

Synthesis and Evaluation of N(6)-Substituted Apioadenosines as Potential Adenosine A(3) Receptor Modulators

Por Toti, Kiran S., Moss, Steven M., Paoletta, Silvia, Gao, Zhan-Guo, Jacobson, Kenneth A., Van Calenbergh, Serge
Publicado em 2014

Design, Synthesis, and Biological Activity of 5′-Phenyl-1,2,5,6-tetrahydro-3,3′-bipyridine Analogues as Potential Antagonists of Nicotinic Acetylcholine Receptors

Por Jin, Yafei, Huang, Xiaoqin, Papke, Roger L., Jutkiewicz, Emily M., Showalter, Hollis D., Zhan, Chang-Guo
Publicado no Bioorg Med Chem Lett (2017)