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Design, Synthesis and Cytotoxic Activity of Novel Sulfonylurea Derivatives of Podophyllotoxin
Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC(50:) 1.41–1.76 μM) and 14e (IC(50): 1.72–2.01 μM) showed superior cytotoxic activity compa...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3902999/ https://ncbi.nlm.nih.gov/pubmed/24332656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.035 |
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