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Design, Synthesis and Cytotoxic Activity of Novel Sulfonylurea Derivatives of Podophyllotoxin

Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC(50:) 1.41–1.76 μM) and 14e (IC(50): 1.72–2.01 μM) showed superior cytotoxic activity compa...

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Main Authors: Zhang, Zhi-Jun, Tian, Jing, Wang, Li-Ting, Wang, Mei-Juan, Nan, Xiang, Yang, Liu, Liu, Ying-Qian, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
格式: Artigo
語言:Inglês
出版: 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902999/
https://ncbi.nlm.nih.gov/pubmed/24332656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.035
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