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Design, Synthesis and Cytotoxic Activity of Novel Sulfonylurea Derivatives of Podophyllotoxin

Three series of novel sulfonylurea podophyllotoxin derivatives were designed, synthesized, and evaluated for in vitro cytotoxicity against four tumor cell lines (A-549, DU-145, KB and KBvin). Compounds 14c (IC(50:) 1.41–1.76 μM) and 14e (IC(50): 1.72–2.01 μM) showed superior cytotoxic activity compa...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Zhang, Zhi-Jun, Tian, Jing, Wang, Li-Ting, Wang, Mei-Juan, Nan, Xiang, Yang, Liu, Liu, Ying-Qian, Morris-Natschke, Susan L., Lee, Kuo-Hsiung
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3902999/
https://ncbi.nlm.nih.gov/pubmed/24332656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2013.11.035
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