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Alkaloids from Oxytropis ochrocephala and Antiproliferative Activity of Sophoridine Derivatives Against Cancer Cell Lines

Ten alkaloids (1−10), with sophoridine (1) as the most abundant component, were obtained from the whole plants of Oxytropis ochrocephala Bunge. Furthermore, eight new sophoridine derivatives (11−16, 20, 21), with modification on the C-14 position of 1 were synthesized. All compounds (1−16, 20, 21) w...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Tan, Cheng-jian, Zhao, Yu, Goto, Masuo, Hsieh, Kan-Yen, Yang, Xiao-ming, Morris-Natschke, Susan L., Liu, Li-na, Zhao, Bao-yu, Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4877041/
https://ncbi.nlm.nih.gov/pubmed/26865176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.09.010
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