BRCA1 haploinsufficiency is masked by RNF168-mediated chromatin ubiquitylation

BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1 deficient cells by in...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Mol Cell
Hauptverfasser: Zong, Dali, Adam, Salomé, Wang, Yifan, Sasanuma, Hiroyuki, Callén, Elsa, Murga, Matilde, Day, Amanda, Kruhlak, Michael J., Wong, Nancy, Munro, Meagan, Chaudhuri, Arnab Ray, Karim, Baktiar, Xia, Bing, Takeda, Shunichi, Johnson, Neil, Durocher, Daniel, Nussenzweig, André
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430682/
https://ncbi.nlm.nih.gov/pubmed/30704900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.010
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge