Molecular Insights into the Function of RING Finger (RNF)-containing Proteins hRNF8 and hRNF168 in Ubc13/Mms2-dependent Ubiquitylation

The repair of DNA double strand breaks by homologous recombination relies on the unique topology of the chains formed by Lys-63 ubiquitylation of chromatin to recruit repair factors such as breast cancer 1 (BRCA1) to sites of DNA damage. The human RING finger (RNF) E3 ubiquitin ligases, RNF8 and RNF...

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Detalhes bibliográficos
Main Authors: Campbell, Stephen J., Edwards, Ross A., Leung, Charles C. Y., Neculai, Dante, Hodge, Curtis D., Dhe-Paganon, Sirano, Glover, J. N. Mark
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3390666/
https://ncbi.nlm.nih.gov/pubmed/22589545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.359653
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