BRCA1 haploinsufficiency is masked by RNF168-mediated chromatin ubiquitylation

BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1 deficient cells by in...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Zong, Dali, Adam, Salomé, Wang, Yifan, Sasanuma, Hiroyuki, Callén, Elsa, Murga, Matilde, Day, Amanda, Kruhlak, Michael J., Wong, Nancy, Munro, Meagan, Chaudhuri, Arnab Ray, Karim, Baktiar, Xia, Bing, Takeda, Shunichi, Johnson, Neil, Durocher, Daniel, Nussenzweig, André
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430682/
https://ncbi.nlm.nih.gov/pubmed/30704900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.010
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados