BRCA1 haploinsufficiency is masked by RNF168-mediated chromatin ubiquitylation

BRCA1 functions at two distinct steps during homologous recombination (HR). Initially, it promotes DNA end resection, and subsequently recruits the PALB2 and BRCA2 mediator complex, which stabilizes RAD51-DNA nucleoprotein filaments. Loss of 53BP1 rescues the HR defect in BRCA1 deficient cells by in...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Zong, Dali, Adam, Salomé, Wang, Yifan, Sasanuma, Hiroyuki, Callén, Elsa, Murga, Matilde, Day, Amanda, Kruhlak, Michael J., Wong, Nancy, Munro, Meagan, Chaudhuri, Arnab Ray, Karim, Baktiar, Xia, Bing, Takeda, Shunichi, Johnson, Neil, Durocher, Daniel, Nussenzweig, André
Format: Artigo
Language:Inglês
Published: 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6430682/
https://ncbi.nlm.nih.gov/pubmed/30704900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.12.010
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