Ectopic expression of RNF168 and 53BP1 increases mutagenic but not physiological non-homologous end joining

DNA double strand breaks (DSBs) formed during S phase are preferentially repaired by homologous recombination (HR), whereas G(1) DSBs, such as those occurring during immunoglobulin class switch recombination (CSR), are repaired by non-homologous end joining (NHEJ). The DNA damage response proteins 5...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Zong, Dali, Callén, Elsa, Pegoraro, Gianluca, Lukas, Claudia, Lukas, Jiri, Nussenzweig, André
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Genome Integrity, Repair and Replication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4446425/
https://ncbi.nlm.nih.gov/pubmed/25916843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv336
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