Modulation of LSD1 phosphorylation by CK2/WIP1 regulates RNF168-dependent 53BP1 recruitment in response to DNA damage

Proper DNA damage response is essential for the maintenance of genome integrity. The E3 ligase RNF168 deficiency fully prevents both the initial recruitment and retention of 53BP1 at sites of DNA damage. In response to DNA damage, RNF168-dependent recruitment of the lysine-specific demethylase LSD1...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Peng, Bin, Wang, Jing, Hu, Yuan, Zhao, Hongli, Hou, Wenya, Zhao, Hongchang, Wang, Hailong, Liao, Ji, Xu, Xingzhi
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499147/
https://ncbi.nlm.nih.gov/pubmed/25999347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv528
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