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Mechanisms of Ubiquitin-Nucleosome Recognition and Regulation of 53BP1 Chromatin Recruitment by RNF168/169 and RAD18

The protein 53BP1 plays a central regulatory role in DNA double-strand break repair. 53BP1 relocates to chromatin by recognizing RNF168-mediated mono-ubiquitylation of histone H2A Lys15 in the nucleosome core particle dimethylated at histone H4 Lys20 (NCP-ubme). 53BP1 relocation is terminated by ubi...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Mol Cell
Asıl Yazarlar: Hu, Qi, Botuyan, Maria Victoria, Cui, Gaofeng, Zhao, Debiao, Mer, Georges
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5523955/
https://ncbi.nlm.nih.gov/pubmed/28506460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.04.009
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