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RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks
Defective signaling or repair of DNA double-strand breaks has been associated with developmental defects and human diseases. The E3 ligase RING finger 168 (RNF168), mutated in the human radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome, was shown to ubiquity...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3876264/ https://ncbi.nlm.nih.gov/pubmed/24324146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320302111 |
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