RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks

Defective signaling or repair of DNA double-strand breaks has been associated with developmental defects and human diseases. The E3 ligase RING finger 168 (RNF168), mutated in the human radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome, was shown to ubiquity...

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Detalles Bibliográficos
Autores principales: Bohgaki, Miyuki, Bohgaki, Toshiyuki, El Ghamrasni, Samah, Srikumar, Tharan, Maire, Georges, Panier, Stephanie, Fradet-Turcotte, Amélie, Stewart, Grant S., Raught, Brian, Hakem, Anne, Hakem, Razqallah
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2013
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3876264/
https://ncbi.nlm.nih.gov/pubmed/24324146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320302111
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